Life Tonics - C60

Bottle, 10 Ml from South Africa (SKU 4663)

Life Tonics C60 is a 'close to saturation' C60 infused MCT oil. Known as a Fullerene molecule after Buckminster Fuller it possesses useful photo, electrochemical and physical properties. It has been indicated as useful for delivering new drug and gene therapies and has many other potential health benefits such in the realms of detoxification, protection from UV rays, reducing inflammation, antibacterial and antiviral properties and promoting longevity. More information below.

Packed in Miron Glass bottles with pipette dropper, containing 10 ml.

C60 (Carbon-60) is a molecule made of 60 carbon atoms that are arranged in a structure which looks like a football. Its shape and stability are what leads it to have some interesting scientific applications, and is the reason it has been hailed as a potential breakthrough in the medical and health supplement worlds.

The purported effects of C60 are nothing short of miraculous, with an experiment conducted in rats even proving that the application of C60-infused olive oil can increase their longevity but up to 90% (Baati, et al 2012). In addition to this, it is well known that fullerenes have beneficial effects on skin and hair health as well as being able to improve osteoarthritic conditions. This is primarily down to the unique antioxidant abilities of C60, in being able to neutralise free radicals, which often build up due to our unhealthy modern lives.

Initial empirical research has been extremely promising; from simply being able to protect against the effects of ageing on the skin, to more radical uses such as treating cancer or HIV, to even having neuroprotectant properties and being a possible treatment for dementia; it is clear to see the potential of C60 and the benefits that having this available to you may bring.

Although now believed to have existed for eons, C60 was only discovered towards the end of the 20th century. As a result, scientific research is ongoing, and therefore there is still much to be learned about the applications of this molecule.

Our new range of 'Life Tonics' is a collection of extracts, tinctures and substances of some of the most powerful and life enhancing herbs and compounds currently available.  Designed to improve both physical and mental energy with potent life enhancing nutrients.  Our herbs are wild harvested in an eco friendly manner during the right seasons and from their indigenous locations. Our tonic herbs are extracted during the peak potency of the plants strength and growth cycle.

Other names: Carbon 60

C60 (Carbon-60), otherwise known as buckminsterfullerene or even colloquially as a buckyball is a molecule which is comprised of 60 carbon atoms arranged in a structure with a similar shape to a football. For centuries it had been thought that the element of carbon existed only as graphite and diamond, however C60 was discovered by a team of scientists in 1985. This was six years after its existence was first hypothesised by Buckminster Fuller who popularised the geodesic dome, and is where the molecule gets its name.

As discussed by Bakry, et al (2007), fullerene molecules are composed entirely of carbon, in the form of a hollow sphere, ellipsoid or tube. An important property of a C60 molecule is its high symmetry: the C60 fullerene surface contains 20 hexagons and 12 pentagons. All the rings are fused; all the double bonds are conjugated. In spite of their extreme conjugation, they behave chemically and physically as electron-deficient alkenes rather than electron rich aromatic systems (Fowler and Ceulemans 1995).

Since the first detection and production of fullerenes, they have gained a prime role on the scientific scene, reaching the pinnacle when the 1996 Nobel Prize for Chemistry was awarded to Kroto, Curl and Smalley for their seminal discovery (Kroto et al 1985). Although only discovered in 1985, there is evidence that C60 actually predates life on Earth, as it has been analysed in deep space as well as terrestrial meteorite samples; even being noted to occur outside of laboratory environments when found in the soot from beeswax candles or lightning strikes in certain conditions.

“[60]Fullerene”, the most abundant representative of the fullerene family was produced for the first time on a preparative scale in 1990, by resistive heating of graphite. This means that an electric discharge is passed across the gap between two carbon electrodes in a low pressure helium atmosphere. The soot that is produced can be mixed with a solvent from which the fullerenes are able to be extracted. (Bakry et al 2007). 

More recently, fullerenes have been produced at a nearly 100% efficiency rate through “surface-catalysed cyclodehydrogenation” (Otero et al 2008). This method utilises platinum as a catalyst to remove hydrogen atoms from aromatic precursors, leaving fullerenes - though crucially none of the platinum is used during the reaction. This development may expedite research in the field as the molecule will now be able to be produced in larger quantities.

Ingredients: C60, MCT oil. We use the Paris protocol meaning the 99.95% solvent free C60 is "infused" for two weeks in the MCT oil. The protocol used results in a close to saturation level of C60 in the MCT oil. A concentration that approximately corresponds to 700-800mg/litre. It is stored in mirror glass bottles as C60 is sensitive to light.  Stored properly like this its shelf life is approximately 2 years.

In recent years, advancements in research and development have led to a surge in application-oriented patents for commercial applications, including; anticancer drug delivery systems, HIV drugs as well as cosmetics to slow down the aging of human skin (Bakry et al 2007).

These fullerene molecules possess useful photo, electrochemical and physical properties, which can be exploited in various medical fields. As an example, fullerenes have been used as a carrier for gene and drug delivery systems. (Bakry et al 2007). Additionally, due to their ability to adsorb and possibly absorb free radicals, they were termed “radical sponges” by Krusic, et al (1991), and this is what provides some of their purported health benefits.

Detox - C60 has been shown to reduce oxidative stress caused by free radicals, termed “oxidative stress-induced apoptosis” (Monti et al 2000). As a result of this, fullerenes are considered to be the world’s most efficient radical scavenger and are described as radical sponges (Krusic et al 1991). C60’s ability to pass through cell membranes is a useful tool to assist with the removal of free radicals within the body, with the potential to leave you feeling cleansed and energised. Furthermore, it is known that “pristine C60” can be considered as a powerful liver-protectant (Bakry et al 2007) which may further enhance the body’s ability to detoxify.

Protect from UV rays - Fullerenes have also been used effectively to combat UVA radiation (Xiao et al 2006). A paper by Bakry, et al (2007) discusses the ability of an augmented C60 molecule (Radical Sponge® [C60 with poly(vinylpyrrolidone)]) “to enter into depth of human skin epidermis due to its stability towards oxidative decomposition makes it more reliable than Vitamin C and enables the prevention of both UV skin-injuries and skin aging, without photosensitization and cytotoxicity.”
Neuroprotectant - Nerves can die off due to overwork and oxidative stress (apoptosis) which, through the targeted application C60 we may be able to mitigate (Dugan et al 1996). Recently, C60 tris(malonic)acid was proven to exhibit robust neuroprotective properties (Bakry et al 2007) and further research in this specific area shows great promise in keeping our brains and bodies healthy and agile. As an example, with regard to Alzheimer’s Disease, it has been shown that augmented fullerenes are able to destroy amyloid-beta plaques, and so this shows great promise for the development of treatments for dementia (Bobylev et al 2011).

Reduces inflammation - A study in recent years has illustrated the efficacy of C60 in reducing inflammation in arthritic rats, which holds promise for comparable therapeutic action in humans with rheumatoid arthritis (Mamontova et al 2013). This, in combination with the remarkable neuroprotective properties of fullerenes may assist people live healthier and more fulfilling lives as the trend of longevity increases.

Antibacterial and antiviral properties - It has been shown that fullerenes have properties which may mean they can be used as bactericides, especially when in conjunction with activated charcoal (Samonin et al 2014)
“Fullerenes (C60) and their derivatives have potential antiviral activity, which has strong implications on the treatment of HIV-infection.” (Bakry et al 2007)

Promotes longevity - Water-soluble C60 has been shown to prevent mitochondrial dysfunction and in one study in particular, rats exposed to fatal doses of radiation were able to survive for 30 days because “pretreatment effectively reduced whole body irradiation-induced mortality without apparent toxicity” (Cai et al 2010). Numerous studies on rats and mice have shown to increase the average lifespan of these animals with varying degrees of efficacy (Quick et al 2008; Baati et al 2012) and specifically that C60 increased the lifespan of mice with acute and chronic neurodegenerative diseases (Dugan et al 1997).

We recommend starting with 2-4 drops in the morning on an empty stomach 10 minutes before any liquid or food. Some people experience detox symptoms even at these low levels but its normal to rapidly progress to about 8 drops a day (of course remembering each person is different). We find that you can take it any time but people generally feel energised and do not sleep as well if they take it in the evening or before bed.

Recommended is to use the Life Tonics extracts daily in measured dosages (see above) daily, rather than high doses infrequently.

The potential toxicity of fullerenes is uncertain at present. Studies show the wide ranging safety of C60; on the otherhand, some concerns have been raised with in vitro studies where LD50 doses were reached in mice. However, other studies were carried out on the biological efficacy of water-soluble fullerenes in vitro (Tsuchiya et al 1995; Dugan et al 1997) and in vivo (Yamago et al 1995; Satoh et al 1997) which indicated low toxicity. 

Although water-soluble fullerenes are not acutely toxic, they are retained in the organism for long periods, raising concerns about chronic toxic effects (Yamago et al 1995). Additionally, there has been little speculation on safety during pregnancy, but it is known that C60 passes straight through the placenta, so it is not advised to consume any form of C60 during pregnancy. However there is striking evidence that hydrophilic functional groups on the surface of fullerenes dramatically decrease toxicity of raw C60 molecule (Sayes et al 2004) (Bakry et al 2007) so again further research is required.

Bakry, R., Vallant, R. M., Najam-ul-Haq, M., Rainer, M., Szabo, Z., Huck, C. W., & Bonn, G. K. (2007). Medicinal applications of fullerenes. International journal of nanomedicine, 2(4), 639–649. 

Baati, T., Bourasset, F., Gharbi, N., Njim, L., Abderrabba, M., Kerkeni, A., Szwarc, H., Moussa, F. (2012). The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene. Biomaterials, 33(19), 4936–4946. 

Kroto, H., Heath, J., O'Brien, S. et al. C60: Buckminsterfullerene. Nature 318, 162–163 (1985).

Monti D, Moretti L, Salvioli S, Straface E, Malorni W, Pellicciari R, Schettini G, Bisaglia M, Pincelli C, Fumelli C, Bonafè M, Franceschi C. (2000). C60 Carboxyfullerene Exerts a Protective Activity against Oxidative Stress-Induced Apoptosis in Human Peripheral Blood Mononuclear Cells. Biochemical and Biophysical Research Communications, 277(3), 711–717.

Galvan YP, Alperovich I, Zolotukhin P, Prazdnova E, Mazanko M, Belanova A, Chistyakov V., (2017) Fullerenes as Anti-Aging Antioxidants, Current Aging Science (2017) 10: 56. 

Chistyakov, V. A., Smirnova, Y. O., Prazdnova, E. V., & Soldatov, A. V. (2013). Possible Mechanisms of Fullerene C60 Antioxidant Action. BioMed Research International, 2013, 1–4. 

Wong-Ekkabut, J., Baoukina, S., Triampo, W., Tang, I.-M., Tieleman, D. P., & Monticelli, L. (2008). Computer simulation study of fullerene translocation through lipid membranes. Nature Nanotechnology, 3(6), 363–368. 

Prylutska, S. V., Matyshevska, O. P., Golub, A. A., Prylutskyy, Y. I., Potebnya, G. P., Ritter, U., & Scharff, P. (2007). Study of C60 fullerenes and C60-containing composites cytotoxicity in vitro. Materials Science and Engineering: C, 27(5-8), 1121–1124. 

Dugan, L. L., Turetsky, D. M., Du, C., Lobner, D., Wheeler, M., Almli, C. R., … Lin, T.-S. (1997). Carboxyfullerenes as neuroprotective agents. Proceedings of the National Academy of Sciences, 94(17), 9434–9439. 

Quick, K. L., Ali, S. S., Arch, R., Xiong, C., Wozniak, D., & Dugan, L. L. (2008). A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice. Neurobiology of Aging, 29(1), 117–128. 

Lin, A. M. Y., Chyi, B. Y., Wang, S. D., Yu, H.-H., Kanakamma, P. P., Luh, T.-Y., … Ho, L. T. (2001). Carboxyfullerene Prevents Iron-Induced Oxidative Stress in Rat Brain. Journal of Neurochemistry, 72(4), 1634–1640.

Dugan, L. L., Gabrielsen, J. K., Yu, S. P., Lin, T.-S., & Choi, D. W. (1996). Buckminsterfullerenol Free Radical Scavengers Reduce Excitotoxic and Apoptotic Death of Cultured Cortical Neurons. Neurobiology of Disease, 3(2), 129–135.  

Fowler, P. W., & Ceulemans, A. (1995). Electron Deficiency of the Fullerenes. The Journal of Physical Chemistry, 99(2), 508–510. 

KRUSIC, P. J., WASSERMAN, E., KEIZER, P. N., MORTON, J. R., & PRESTON, K. F. (1991). Radical Reactions of C60. Science, 254(5035), 1183–1185. doi:10.1126/science.254.5035.1183

Dugan, L. L., Lovett, E. G., Quick, K. L., Lotharius, J., Lin, T. T., & O’Malley, K. L. (2001). Fullerene-based antioxidants and neurodegenerative disorders. Parkinsonism & Related Disorders, 7(3), 243–246. 

Wolff, D. J., Papoiu, A. D. P., Mialkowski, K., Richardson, C. F., Schuster, D. I., & Wilson, S. R. (2000). Inhibition of Nitric Oxide Synthase Isoforms by Tris-Malonyl-C60-Fullerene Adducts. Archives of Biochemistry and Biophysics, 378(2), 216–223. 

Liu, Q., Jin, L., Shen, F. H., Balian, G., & Li, X. J. (2013). Fullerol nanoparticles suppress inflammatory response and adipogenesis of vertebral bone marrow stromal cells—a potential novel treatment for intervertebral disc degeneration. The Spine Journal, 13(11), 1571–1580. 

Yudoh, K., Shishido, K., Murayama, H., Yano, M., Matsubayashi, K., Takada, H., … Nishioka, K. (2007). Water-soluble C60 fullerene prevents degeneration of articular cartilage in osteoarthritis via down-regulation of chondrocyte catabolic activity and inhibition of cartilage degeneration during disease development. Arthritis & Rheumatism, 56(10), 3307–3318. 

Aly, F. M., Othman, A., & Haridy, M. (2018). Protective Effects of Fullerene C60 Nanoparticles and Virgin Olive Oil against Genotoxicity Induced by Cyclophosphamide in Rats. Oxidative medicine and cellular longevity 

Ali, S. S., Hardt, J. I., Quick, K. L., Sook Kim-Han, J., Erlanger, B. F., Huang, T., Epstein C. J., Dugan, L. L. (2004). A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties. Free Radical Biology and Medicine, 37(8), 1191–1202. 

Mamontova, TV., Mykytiuk, MV., Bobrova, NO., Kutsenko, LO., Vesnina, LE., Kaidashev, IP. (2013). The anti-inflammatory effect of fullerene C60 on adjuvant arthritis in rats. Fiziol Zh. 59(3), 102-110.

Kuo, W.-S., Weng, C.-T., Chen, J.-H., Wu, C.-L., Shiau, A.-L., Hsieh, J.-L., So, EC., Wu, P.-T., Chen, S.-Y. (2019). Amelioration of Experimentally Induced Arthritis by Reducing Reactive Oxygen Species Production through the Intra-Articular Injection of Water-Soluble Fullerenol. Nanomaterials, 9(6), 909. 

Samonin, V. V., Spiridonova, E. A., Podvyaznikov, M. L., & Tikhomirova, A. D. (2014). Study of sorption and bactericidal properties of carbon adsorbents and fullerenes. Russian Journal of Applied Chemistry, 87(7), 990–993. 

Cai, X., Hao, J., Zhang, X., Yu, B., Ren, J., Luo, C., Li, Q., Huang, Q., Shi, X., Li, W., Liu, J. (2010). The polyhydroxylated fullerene derivative C60(OH)24 protects mice from ionizing-radiation-induced immune and mitochondrial dysfunction. Toxicology and Applied Pharmacology, 243(1), 27–34.

Bobylev, A. G., Kornev, A. B., Bobyleva, L. G., Shpagina, M. D., Fadeeva, I. S., Fadeev, R. S., Deryabin, D.G., Balzarini, J., Troshin, P.A., Podlubnaya, Z. A. (2011). Fullerenolates: metallated polyhydroxylated fullerenes with potent anti-amyloid activity. Organic & Biomolecular Chemistry, 9(16), 5714. 

Otero, G., Biddau, G., Sánchez-Sánchez, C., Caillard, R., López, M. F., Rogero, C., Martín-Gago, J. A. (2008). Fullerenes from aromatic precursors by surface-catalysed cyclodehydrogenation. Nature, 454(7206), 865–868. 

Related items ...